Impaired osteoclastic bone resorption leads to osteopetrosis in cathepsin-K-deficient mice

Cathepsin K is a recently identified lysosomal cysteine proteinase. It is abundant in osteoclasts, where it is believed to play a vital role in the resorption and remodeling of bone. Pycnodysostosis is a rare inherited osteochondrodysplasia that is caused by mutations of the cathepsin-K gene, charac...

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Bibliografische gegevens
Hoofdauteurs: Saftig, Paul, Hunziker, Ernst, Wehmeyer, Olaf, Jones, Sheila, Boyde, Alan, Rommerskirch, Winfried, Moritz, Jörg Detlev, Schu, Peter, von Figura, Kurt
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: The National Academy of Sciences 1998
Onderwerpen:
Biological Sciences
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC24840/
https://ncbi.nlm.nih.gov/pubmed/9811821
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