Immune tolerance improves the efficacy of enzyme replacement therapy in canine mucopolysaccharidosis I

Mucopolysaccharidoses (MPSs) are lysosomal storage diseases caused by a deficit in the enzymes needed for glycosaminoglycan (GAG) degradation. Enzyme replacement therapy with recombinant human α-l-iduronidase successfully reduces lysosomal storage in canines and humans with iduronidase-deficient MPS...

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Main Authors: Dickson, Patricia, Peinovich, Maryn, McEntee, Michael, Lester, Thomas, Le, Steven, Krieger, Aimee, Manuel, Hayden, Jabagat, Catherine, Passage, Merry, Kakkis, Emil D.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Clinical Investigation 2008
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2483682/
https://ncbi.nlm.nih.gov/pubmed/18654665
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI34676
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