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Intrathecal enzyme replacement therapy: Successful treatment of brain disease via the cerebrospinal fluid
Treatment of brain disease with recombinant proteins is difficult due to the blood-brain barrier. As an alternative to direct injections into the brain, we studied whether application of high concentrations of therapeutic enzymes via intrathecal (IT) injections could successfully drive uptake across...
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| Main Authors: | , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3009387/ https://ncbi.nlm.nih.gov/pubmed/17321776 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ymgme.2006.12.012 |
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