Glycosaminoglycan storage in neuroanatomical regions of mucopolysaccharidosis I dogs following intrathecal recombinant human iduronidase

Intrathecal (IT) recombinant human α-L-iduronidase (rhIDU) has been shown to reduce mean brain glycosaminoglycans (GAGs) to normal levels in MPS I dogs. In this study, we examined storage in neuroanatomical regions of the MPS I dog brain, including frontal lobe, cerebellum, basal ganglia, thalamus,...

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Detalhes bibliográficos
Main Authors: Chen, Agnes, Vogler, Carole, McEntee, Michael, Hanson, Stephen, Ellinwood, Matthew, Jens, Jackie, Snella, Elizabeth, Passage, Merry, Le, Steven, Guerra, Catalina, Dickson, Patricia
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3137268/
https://ncbi.nlm.nih.gov/pubmed/21749451
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1600-0463.2011.02760.x
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