Specific antibody titer alters the effectiveness of intrathecal enzyme replacement therapy in canine mucopolysaccharidosis I

Intrathecal enzyme replacement therapy is an experimental option to treat central nervous system disease due to lysosomal storage. Previous work shows that MPS I dogs receiving enzyme replacement with recombinant human alpha-L-iduronidase into the cisterna magna showed normal brain glycosaminoglycan...

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Detalhes bibliográficos
Main Authors: Dickson, Patricia I., Ellinwood, N. Matthew, Brown, Jillian R., Witt, Robert G., Le, Steven Q., Passage, Merry B., Vera, Moin U., Crawford, Brett E.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3336016/
https://ncbi.nlm.nih.gov/pubmed/22402327
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ymgme.2012.02.003
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