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Stoichiometric Pore Mutations of the GABA(A)R Reveal a Pattern of Hydrogen Bonding with Picrotoxin
Picrotoxin (PTX) is a noncompetitive antagonist of many ligand-gated ion channels, with a site of action believed to be within the ion-conducting pore. In the A-type gamma-aminobutyric acid receptor, a threonine residue in the second transmembrane domain is of particular importance for the binding o...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
The Biophysical Society
2008
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2480680/ https://ncbi.nlm.nih.gov/pubmed/18310243 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1529/biophysj.107.118455 |
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