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Stoichiometric Pore Mutations of the GABA(A)R Reveal a Pattern of Hydrogen Bonding with Picrotoxin

Picrotoxin (PTX) is a noncompetitive antagonist of many ligand-gated ion channels, with a site of action believed to be within the ion-conducting pore. In the A-type gamma-aminobutyric acid receptor, a threonine residue in the second transmembrane domain is of particular importance for the binding o...

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Detalhes bibliográficos
Main Authors: Erkkila, Brian E., Sedelnikova, Anna V., Weiss, David S.
Formato: Artigo
Idioma:Inglês
Publicado em: The Biophysical Society 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2480680/
https://ncbi.nlm.nih.gov/pubmed/18310243
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1529/biophysj.107.118455
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