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Hydrogen-Bonding Dynamics between Adjacent Blades in G-Protein β-Subunit Regulates GIRK Channel Activation
Functionally critical domains in the βγ-subunits of the G-protein (Gβγ) do not undergo large structural rearrangements upon binding to other proteins. Here we show that a region containing Ser(67) and Asp(323) of Gβγ is a critical determinant of G-protein-gated inwardly rectifying K(+) (GIRK) channe...
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| Главные авторы: | , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Biophysical Society
2006
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1414569/ https://ncbi.nlm.nih.gov/pubmed/16428273 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1529/biophysj.105.069302 |
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