Hydrogen-Bonding Dynamics between Adjacent Blades in G-Protein β-Subunit Regulates GIRK Channel Activation

Functionally critical domains in the βγ-subunits of the G-protein (Gβγ) do not undergo large structural rearrangements upon binding to other proteins. Here we show that a region containing Ser(67) and Asp(323) of Gβγ is a critical determinant of G-protein-gated inwardly rectifying K(+) (GIRK) channe...

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Detaylı Bibliyografya
Asıl Yazarlar: Mirshahi, Tooraj, Logothetis, Diomedes E., Rosenhouse-Dantsker, Avia
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Biophysical Society 2006
Konular:
Channels, Receptors, and Electrical Signaling
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC1414569/
https://ncbi.nlm.nih.gov/pubmed/16428273
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1529/biophysj.105.069302
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