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Cholesterol Sensitivity of KIR2.1 Is Controlled by a Belt of Residues around the Cytosolic Pore

Kir channels play an important role in setting the resting membrane potential and modulating membrane excitability. A common feature of several Kir channels is that they are regulated by cholesterol. Yet, the mechanism by which cholesterol affects channel function is unclear. We recently showed that...

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Autors principals: Rosenhouse-Dantsker, Avia, Logothetis, Diomedes E., Levitan, Irena
Format: Artigo
Idioma:Inglês
Publicat: The Biophysical Society 2011
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3021658/
https://ncbi.nlm.nih.gov/pubmed/21244834
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2010.11.086
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