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Structural Rearrangements in Loop F of the GABA Receptor Signal Ligand Binding, Not Channel Activation
Structure-function studies of the Cys loop family of ionotropic neurotransmitter receptors (GABA, nACh, 5-HT(3), and glycine receptors) have resulted in a six-loop (A–F) model of the agonist-binding site. Key amino acids have been identified in these loops that associate with, and stabilize, bound l...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The Biophysical Society
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2710018/ https://ncbi.nlm.nih.gov/pubmed/19134470 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2008.09.011 |
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