Structural Rearrangements in Loop F of the GABA Receptor Signal Ligand Binding, Not Channel Activation

Structure-function studies of the Cys loop family of ionotropic neurotransmitter receptors (GABA, nACh, 5-HT(3), and glycine receptors) have resulted in a six-loop (A–F) model of the agonist-binding site. Key amino acids have been identified in these loops that associate with, and stabilize, bound l...

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Bibliografiske detaljer
Main Authors: Khatri, Alpa, Sedelnikova, Anna, Weiss, David S.
Format: Artigo
Sprog:Inglês
Udgivet: The Biophysical Society 2009
Fag:
Channels, Receptors, and Electrical Signaling
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2710018/
https://ncbi.nlm.nih.gov/pubmed/19134470
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2008.09.011
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