Stoichiometry of a pore mutation that abolishes picrotoxin-mediated antagonism of the GABA(A) receptor

Picrotoxin, a potent antagonist of the inhibitory central nervous system GABA(A) and glycine receptors, is believed to interact with residues that line the central ion pore. These pore-lining residues are in the second transmembrane domain (TM2) of each of the five constituent subunits. One of these...

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Hlavní autoři: Sedelnikova, Anna, Erkkila, Brian E, Harris, Holly, Zakharkin, Stanislav O, Weiss, David S
Médium: Artigo
Jazyk:Inglês
Vydáno: Blackwell Science Inc 2006
Témata:
Neuroscience
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1890441/
https://ncbi.nlm.nih.gov/pubmed/16990398
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2006.120287
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