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Stoichiometry of a pore mutation that abolishes picrotoxin-mediated antagonism of the GABA(A) receptor
Picrotoxin, a potent antagonist of the inhibitory central nervous system GABA(A) and glycine receptors, is believed to interact with residues that line the central ion pore. These pore-lining residues are in the second transmembrane domain (TM2) of each of the five constituent subunits. One of these...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Blackwell Science Inc
2006
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1890441/ https://ncbi.nlm.nih.gov/pubmed/16990398 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2006.120287 |
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