Reduced Threshold for Luminal Ca(2+) Activation of RyR1 Underlies a Causal Mechanism of Porcine Malignant Hyperthermia

Gelijkaardige items

• Reduced threshold for store overload-induced Ca(2+) release is a common defect of RyR1 mutations associated with malignant hyperthermia and central core disease
  door: Chen, Wenqian, et al.
  Gepubliceerd in: (2017)
• RyR2 mutations linked to ventricular tachycardia and sudden death reduce the threshold for store-overload-induced Ca(2+) release (SOICR)
  door: Jiang, Dawei, et al.
  Gepubliceerd in: (2004)
• Binding of RyR2 “Unzipping” Peptide in Cardiomyocytes Activates RyR2 and Reciprocally Inhibits Calmodulin Binding
  door: Oda, Tetsuro, et al.
  Gepubliceerd in: (2012)
• Divergent effects of the malignant hyperthermia-susceptible Arg(615)-->Cys mutation on the Ca(2+) and Mg(2+) dependence of the RyR1.
  door: Balog, E M, et al.
  Gepubliceerd in: (2001)
• Abnormal Termination of Ca(2+) Release Is a Common Defect of RyR2 Mutations Associated With Cardiomyopathies
  door: Tang, Yijun, et al.
  Gepubliceerd in: (2012)