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Reduced Threshold for Luminal Ca(2+) Activation of RyR1 Underlies a Causal Mechanism of Porcine Malignant Hyperthermia
Naturally occurring mutations in the skeletal muscle Ca(2+) release channel/ryanodine receptor RyR1 are linked to malignant hyperthermia (MH), a life-threatening complication of general anesthesia. Although it has long been recognized that MH results from uncontrolled or spontaneous Ca(2+) release f...
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| Main Authors: | , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2475718/ https://ncbi.nlm.nih.gov/pubmed/18505726 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M801944200 |
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