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RyR2 mutations linked to ventricular tachycardia and sudden death reduce the threshold for store-overload-induced Ca(2+) release (SOICR)
The cardiac ryanodine receptor (RyR2) governs the release of Ca(2+) from the sarcoplasmic reticulum, which initiates muscle contraction. Mutations in RyR2 have been linked to ventricular tachycardia (VT) and sudden death, but the precise molecular mechanism is unclear. It is known that when the sarc...
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| Hlavní autoři: | , , , , , , , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
National Academy of Sciences
2004
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC516517/ https://ncbi.nlm.nih.gov/pubmed/15322274 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0402388101 |
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