Divergent effects of the malignant hyperthermia-susceptible Arg(615)-->Cys mutation on the Ca(2+) and Mg(2+) dependence of the RyR1.

The sarcoplasmic reticulum (SR) Ca(2+) release channel (RyR1) from malignant hyperthermia-susceptible (MHS) porcine skeletal muscle has a decreased sensitivity to inhibition by Mg(2+). This diminished Mg(2+) inhibition has been attributed to a lower Mg(2+) affinity of the inhibition (I) site. To det...

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Detalles Bibliográficos
Main Authors: Balog, E M, Fruen, B R, Shomer, N H, Louis, C F
Formato: Artigo
Idioma:Inglês
Publicado: 2001
Assuntos:
Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC1301678/
https://ncbi.nlm.nih.gov/pubmed/11566777
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