Malignant hyperthermia mutation Arg615Cys in the porcine ryanodine receptor alters voltage dependence of Ca(2+) release

1. Ca(2+) inward current and fura-2 Ca(2+) transients were simultaneously recorded in porcine myotubes. Myotubes from normal pigs and cells from specimens homozygous for the Arg615Cys (malignant hyperthermia) mutation of the skeletal muscle ryanodine receptor RyR1 were investigated. We addressed the...

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Detalhes bibliográficos
Main Authors: Dietze, B, Henke, J, Eichinger, H M, Lehmann-Horn, F, Melzer, W
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Science Inc 2000
Assuntos:
Rapid Report
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2270038/
https://ncbi.nlm.nih.gov/pubmed/10922003
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1469-7793.2000.t01-1-00507.x
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