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Effect of linkage geometry on biological activity in thiourea- and guanidine-substituted acridines and platinum–acridines
Novel thiourea- and guanidine-modified acridine-4-carboxamides (4, 7) and a corresponding platinum–intercalator conjugate (4′) have been synthesized and evaluated as cytotoxic agents in human promyelocytic leukemia, HL-60, and a non-small cell lung cancer, NCI-H460. Modification of thiourea sulfur i...
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| Main Authors: | , , , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
2008
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2474763/ https://ncbi.nlm.nih.gov/pubmed/18515101 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2008.05.043 |
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