Mre11–Rad50–Nbs1-dependent processing of DNA breaks generates oligonucleotides that stimulate ATM activity

DNA double-strand breaks (DSBs) can be processed by the Mre11–Rad50–Nbs1 (MRN) complex, which is essential to promote ataxia telangiectasia-mutated (ATM) activation. However, the molecular mechanisms linking MRN activity to ATM are not fully understood. Here, using Xenopus laevis egg extract we show...

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Hlavní autoři: Jazayeri, Ali, Balestrini, Alessia, Garner, Elizabeth, Haber, James E, Costanzo, Vincenzo
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2008
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2453060/
https://ncbi.nlm.nih.gov/pubmed/18596698
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2008.128
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