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The Mre11-Rad50-Nbs1 Complex Mediates Activation of TopBP1 by ATM

The activation of ATR-ATRIP in response to double-stranded DNA breaks (DSBs) depends upon ATM in human cells and Xenopus egg extracts. One important aspect of this dependency involves regulation of TopBP1 by ATM. In Xenopus egg extracts, ATM associates with TopBP1 and thereupon phosphorylates it on...

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Main Authors: Yoo, Hae Yong, Kumagai, Akiko, Shevchenko, Anna, Shevchenko, Andrej, Dunphy, William G.
Formato: Artigo
Idioma:Inglês
Publicado: The American Society for Cell Biology 2009
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2675615/
https://ncbi.nlm.nih.gov/pubmed/19279141
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E08-12-1190
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