CtIP interacts with TopBP1 and Nbs1 in the response to double-stranded DNA breaks (DSBs) in Xenopus egg extracts

In the presence of double-stranded DNA breaks (DSBs), the activation of ATR is achieved by the ability of ATM to phosphorylate TopBP1 on serine 1131, which leads to an enhancement of the interaction between ATR and TopBP1. In Xenopus egg extracts, the Mre11-Rad50-Nbs1 (MRN) complex is additionally r...

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Autori principali: Ramírez-Lugo, Juan S, Yoo, Hae Yong, Yoon, Su Jin, Dunphy, William G
Natura: Artigo
Lingua:Inglês
Pubblicazione: Landes Bioscience 2011
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3115019/
https://ncbi.nlm.nih.gov/pubmed/21263215
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cc.10.3.14711
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