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Importin β-dependent nuclear import of TopBP1 in ATR-Chk1 checkpoint in Xenopus egg extracts

TopBP1, a multiple-BRCT-containing protein, plays diverse functions in DNA metabolism including DNA replication, DNA damage response and transcriptional regulation. The cytoplasmic localization of TopBP1 has been found associated with breast cancer susceptibility in clinical studies, suggesting the...

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Detalhes bibliográficos
Main Authors: Bai, Liping, Michael, W. Matthew, Yan, Shan
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3951582/
https://ncbi.nlm.nih.gov/pubmed/24440306
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cellsig.2014.01.006
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