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The Mre11-Rad50-Nbs1 Complex Mediates Activation of TopBP1 by ATM
The activation of ATR-ATRIP in response to double-stranded DNA breaks (DSBs) depends upon ATM in human cells and Xenopus egg extracts. One important aspect of this dependency involves regulation of TopBP1 by ATM. In Xenopus egg extracts, ATM associates with TopBP1 and thereupon phosphorylates it on...
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| Hlavní autoři: | , , , , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
The American Society for Cell Biology
2009
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2675615/ https://ncbi.nlm.nih.gov/pubmed/19279141 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E08-12-1190 |
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