Mre11–Rad50–Nbs1-dependent processing of DNA breaks generates oligonucleotides that stimulate ATM activity

DNA double-strand breaks (DSBs) can be processed by the Mre11–Rad50–Nbs1 (MRN) complex, which is essential to promote ataxia telangiectasia-mutated (ATM) activation. However, the molecular mechanisms linking MRN activity to ATM are not fully understood. Here, using Xenopus laevis egg extract we show...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Jazayeri, Ali, Balestrini, Alessia, Garner, Elizabeth, Haber, James E, Costanzo, Vincenzo
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group 2008
Materias:
Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2453060/
https://ncbi.nlm.nih.gov/pubmed/18596698
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2008.128
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!

Ejemplares similares