Mre11–Rad50–Nbs1-dependent processing of DNA breaks generates oligonucleotides that stimulate ATM activity

DNA double-strand breaks (DSBs) can be processed by the Mre11–Rad50–Nbs1 (MRN) complex, which is essential to promote ataxia telangiectasia-mutated (ATM) activation. However, the molecular mechanisms linking MRN activity to ATM are not fully understood. Here, using Xenopus laevis egg extract we show...

Full beskrivning

Sparad:
Bibliografiska uppgifter
Huvudupphovsmän: Jazayeri, Ali, Balestrini, Alessia, Garner, Elizabeth, Haber, James E, Costanzo, Vincenzo
Materialtyp: Artigo
Språk:Inglês
Publicerad: Nature Publishing Group 2008
Ämnen:
Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2453060/
https://ncbi.nlm.nih.gov/pubmed/18596698
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2008.128
Taggar: Lägg till en tagg
Inga taggar, Lägg till första taggen!

Liknande verk