Synthesis of 5′-Functionalized Nucleosides: S-Adenosylhomocysteine Analogues with the Carbon-5′ and Sulfur Atoms Replaced by a Vinyl or Halovinyl Unit

Adenosine and uridine analogues functionalized with alkenyl or fluoroalkenyl chain at C5′ were prepared employing cross-metathesis, Negishi couplings and Wittig reactions. Metathesis of the protected 5′-deoxy-5′-methyleneadenosine or uridine analogues with six-carbon amino acids (homoallylglycines)...

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Hlavní autoři: Wnuk, Stanislaw F., Sacasa, Pablo R., Lewandowska, Elzbieta, Andrei, Daniela, Cai, Sumin, Borchardt, Ronald T.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2008
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2443866/
https://ncbi.nlm.nih.gov/pubmed/18457953
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2008.04.017
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