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Targeting the PI3K/Akt/mTOR pathway: effective combinations and clinical considerations
The PI3K/Akt/mTOR pathway is a prototypic survival pathway that is constitutively activated in many types of cancer. Mechanisms for pathway activation include loss of tumor suppressor PTEN function, amplification or mutation of PI3K, amplification or mutation of Akt, activation of growth factor rece...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2442829/ https://ncbi.nlm.nih.gov/pubmed/18166498 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.drup.2007.11.003 |
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