Structural origins of the exonuclease resistance of a zwitterionic RNA

Nuclease resistance and RNA affinity are key criteria in the search for optimal antisense nucleic acid modifications, but the origins of the various levels of resistance to nuclease degradation conferred by chemical modification of DNA and RNA are currently not understood. The 2′-O-aminopropyl (AP)-...

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Detalles Bibliográficos

Publicado en:	Proc Natl Acad Sci U S A
Principais autores:	Teplova, Marianna, Wallace, Scot T., Tereshko, Valentina, Minasov, George, Symons, Alice M., Cook, P. Dan, Manoharan, Muthiah, Egli, Martin
Formato:	Artigo
Idioma:	Inglês
Publicado:	National Academy of Sciences 1999
Assuntos:	Biological Sciences
Acceso en liña:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC24421/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10588690/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.96.25.14240
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