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Structural origins of the exonuclease resistance of a zwitterionic RNA

Nuclease resistance and RNA affinity are key criteria in the search for optimal antisense nucleic acid modifications, but the origins of the various levels of resistance to nuclease degradation conferred by chemical modification of DNA and RNA are currently not understood. The 2′-O-aminopropyl (AP)-...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Proc Natl Acad Sci U S A
Prif Awduron: Teplova, Marianna, Wallace, Scot T., Tereshko, Valentina, Minasov, George, Symons, Alice M., Cook, P. Dan, Manoharan, Muthiah, Egli, Martin
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: National Academy of Sciences 1999
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC24421/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10588690/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.96.25.14240
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