IRE1β Inhibits Chylomicron Production by Selectively Degrading MTP mRNA

Microsomal triglyceride transfer protein (MTP) is needed to assemble chylomicrons in the endoplasmic reticulum (ER) of enterocytes. We explored the role of an ER stress protein, inositol-requiring enzyme 1β (IRE1β), in regulating this process. High-cholesterol and high-fat diets decreased intestinal...

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Huvudupphovsmän: Iqbal, Jahangir, Dai, Kezhi, Seimon, Tracie, Jungreis, Rivka, Oyadomari, Miho, Kuriakose, George, Ron, David, Tabas, Ira, Hussain, M. Mahmood
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2008
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2435513/
https://ncbi.nlm.nih.gov/pubmed/18460335
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2008.03.005
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