IRE1β Inhibits Chylomicron Production by Selectively Degrading MTP mRNA

Microsomal triglyceride transfer protein (MTP) is needed to assemble chylomicrons in the endoplasmic reticulum (ER) of enterocytes. We explored the role of an ER stress protein, inositol-requiring enzyme 1β (IRE1β), in regulating this process. High-cholesterol and high-fat diets decreased intestinal...

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Main Authors: Iqbal, Jahangir, Dai, Kezhi, Seimon, Tracie, Jungreis, Rivka, Oyadomari, Miho, Kuriakose, George, Ron, David, Tabas, Ira, Hussain, M. Mahmood
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2008
Ábhair:
Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2435513/
https://ncbi.nlm.nih.gov/pubmed/18460335
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2008.03.005
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