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IRE1β Inhibits Chylomicron Production by Selectively Degrading MTP mRNA

Microsomal triglyceride transfer protein (MTP) is needed to assemble chylomicrons in the endoplasmic reticulum (ER) of enterocytes. We explored the role of an ER stress protein, inositol-requiring enzyme 1β (IRE1β), in regulating this process. High-cholesterol and high-fat diets decreased intestinal...

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書誌詳細
主要な著者: Iqbal, Jahangir, Dai, Kezhi, Seimon, Tracie, Jungreis, Rivka, Oyadomari, Miho, Kuriakose, George, Ron, David, Tabas, Ira, Hussain, M. Mahmood
フォーマット: Artigo
言語:Inglês
出版事項: 2008
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC2435513/
https://ncbi.nlm.nih.gov/pubmed/18460335
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2008.03.005
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