Reduced Apoptosis and Plaque Necrosis in Advanced Atherosclerotic Lesions of Apoe−/− and Ldlr−/− Mice Lacking CHOP

Endoplasmic reticulum (ER) stress is a hallmark of advanced atherosclerosis, but its causative role in plaque progression is unknown. In-vitro studies have implicated the ER stress effector CHOP in macrophage apoptosis, a process involved in plaque necrosis in advanced atheromata. To test the effect...

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Bibliographic Details
Main Authors: Thorp, Edward, Li, Gang, Seimon, Tracie A., Kuriakose, George, Ron, David, Tabas, Ira
Format: Artigo
Language:Inglês
Published: 2009
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2695925/
https://ncbi.nlm.nih.gov/pubmed/19416717
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2009.03.003
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