Macrophage deficiency of p38α MAPK promotes apoptosis and plaque necrosis in advanced atherosclerotic lesions in mice

ER stress occurs in macrophage-rich areas of advanced atherosclerotic lesions and contributes to macrophage apoptosis and subsequent plaque necrosis. Therefore, signaling pathways that alter ER stress–induced apoptosis may affect advanced atherosclerosis. Here we placed Apoe(–/–) mice deficient in m...

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Autors principals: Seimon, Tracie A., Wang, Yibin, Han, Seongah, Senokuchi, Takafumi, Schrijvers, Dorien M., Kuriakose, George, Tall, Alan R., Tabas, Ira A.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Clinical Investigation 2009
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Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2662559/
https://ncbi.nlm.nih.gov/pubmed/19287091
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI37262
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