Destabilization of ATP-sensitive Potassium Channel Activity by Novel KCNJ11 Mutations Identified in Congenital Hyperinsulinism

The inwardly rectifying potassium channel Kir6.2 is the pore-forming subunit of the ATP-sensitive potassium (K(ATP)) channel, which controls insulin secretion by coupling glucose metabolism to membrane potential in β-cells. Loss of channel function because of mutations in Kir6.2 or its associated re...

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Detalhes bibliográficos
Main Authors: Lin, Yu-Wen, Bushman, Jeremy D., Yan, Fei-Fei, Haidar, Sara, MacMullen, Courtney, Ganguly, Arupa, Stanley, Charles A., Shyng, Show-Ling
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2008
Assuntos:
Membrane Transport, Structure, Function, and Biogenesis
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2431039/
https://ncbi.nlm.nih.gov/pubmed/18250167
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M708798200
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