Clinical characteristics and biochemical mechanisms of congenital hyperinsulinism associated with dominant K(ATP )channel mutations

Congenital hyperinsulinism is a condition of dysregulated insulin secretion often caused by inactivating mutations of the ATP-sensitive K(+) (K(ATP)) channel in the pancreatic β cell. Though most disease-causing mutations of the 2 genes encoding K(ATP) subunits, ABCC8 (SUR1) and KCNJ11 (Kir6.2), are...

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Détails bibliographiques
Auteurs principaux: Pinney, Sara E., MacMullen, Courtney, Becker, Susan, Lin, Yu-Wen, Hanna, Cheryl, Thornton, Paul, Ganguly, Arupa, Shyng, Show-Ling, Stanley, Charles A.
Format: Artigo
Langue:Inglês
Publié: American Society for Clinical Investigation 2008
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2441858/
https://ncbi.nlm.nih.gov/pubmed/18596924
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI35414
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