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Clinical characteristics and biochemical mechanisms of congenital hyperinsulinism associated with dominant K(ATP )channel mutations
Congenital hyperinsulinism is a condition of dysregulated insulin secretion often caused by inactivating mutations of the ATP-sensitive K(+) (K(ATP)) channel in the pancreatic β cell. Though most disease-causing mutations of the 2 genes encoding K(ATP) subunits, ABCC8 (SUR1) and KCNJ11 (Kir6.2), are...
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| Główni autorzy: | , , , , , , , , |
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| Format: | Artigo |
| Język: | Inglês |
| Wydane: |
American Society for Clinical Investigation
2008
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| Hasła przedmiotowe: | |
| Dostęp online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2441858/ https://ncbi.nlm.nih.gov/pubmed/18596924 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI35414 |
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