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A NOVEL KCNJ11 MUTATION ASSOCIATED WITH CONGENITAL HYPERINSULINISM REDUCES THE INTRINSIC OPEN PROBABILITY OF β-CELL ATP-SENSITIVE POTASSIUM CHANNELS

The β-cell ATP-sensitive potassium (K(ATP)) channel controls insulin secretion by linking glucose metabolism to membrane excitability. Loss of K(ATP) channel function due to mutations in ABCC8 or KCNJ11, genes that encode the sulfonylurea receptor 1 or the inward rectifier Kir6.2 subunit of the chan...

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Bibliografiske detaljer
Main Authors: Lin, Yu-Wen, MacMullen, Courtney, Ganguly, Arupa, Stanley, Charles A., Shyng, Show-Ling
Format: Artigo
Sprog:Inglês
Udgivet: 2005
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1479853/
https://ncbi.nlm.nih.gov/pubmed/16332676
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M511875200
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