A NOVEL KCNJ11 MUTATION ASSOCIATED WITH CONGENITAL HYPERINSULINISM REDUCES THE INTRINSIC OPEN PROBABILITY OF β-CELL ATP-SENSITIVE POTASSIUM CHANNELS

The β-cell ATP-sensitive potassium (K(ATP)) channel controls insulin secretion by linking glucose metabolism to membrane excitability. Loss of K(ATP) channel function due to mutations in ABCC8 or KCNJ11, genes that encode the sulfonylurea receptor 1 or the inward rectifier Kir6.2 subunit of the chan...

Descrición completa

Gardado en:
Detalles Bibliográficos
Main Authors: Lin, Yu-Wen, MacMullen, Courtney, Ganguly, Arupa, Stanley, Charles A., Shyng, Show-Ling
Formato: Artigo
Idioma:Inglês
Publicado: 2005
Assuntos:
Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC1479853/
https://ncbi.nlm.nih.gov/pubmed/16332676
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M511875200
Tags: Engadir etiqueta
Sen Etiquetas, Sexa o primeiro en etiquetar este rexistro!

Títulos similares