Characterization and Functional Restoration of a Potassium Channel Kir6.2 Pore Mutation Identified in Congenital Hyperinsulinism

The inwardly rectifying potassium channel Kir6.2 assembles with sulfonylurea receptor 1 to form the ATP-sensitive potassium (K(ATP)) channels that regulate insulin secretion in pancreatic β-cells. Mutations in K(ATP) channels underlie insulin secretion disease. Here, we report the characterization o...

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Detalhes bibliográficos
Main Authors: Bushman, Jeremy D., Gay, Joel W., Tewson, Paul, Stanley, Charles A., Shyng, Show-Ling
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2010
Assuntos:
Molecular Biophysics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2825395/
https://ncbi.nlm.nih.gov/pubmed/20032456
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.085860
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