ATP activates ATP-sensitive potassium channels composed of mutant sulfonylurea receptor 1 and Kir6.2 with diminished PIP(2) sensitivity

ATP-sensitive potassium (K(ATP)) channels are inhibited by ATP and activated by phosphatidylinositol-4,5-bisphosphate (PIP(2)). Both channel subunits Kir6.2 and sulfonylurea receptor 1 (SUR1) contribute to gating: while Kir6.2 interacts with ATP and PIP(2), SUR1 enhances sensitivity to both ligands....

Celý popis

Uloženo v:
Podrobná bibliografie
Hlavní autoři: Pratt, Emily B, Shyng, Show-Ling
Médium: Artigo
Jazyk:Inglês
Vydáno: Landes Bioscience 2011
Témata:
Article Addendum
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3225731/
https://ncbi.nlm.nih.gov/pubmed/21654216
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/chan.5.4.16510
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky