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ATP activates ATP-sensitive potassium channels composed of mutant sulfonylurea receptor 1 and Kir6.2 with diminished PIP(2) sensitivity
ATP-sensitive potassium (K(ATP)) channels are inhibited by ATP and activated by phosphatidylinositol-4,5-bisphosphate (PIP(2)). Both channel subunits Kir6.2 and sulfonylurea receptor 1 (SUR1) contribute to gating: while Kir6.2 interacts with ATP and PIP(2), SUR1 enhances sensitivity to both ligands....
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Landes Bioscience
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3225731/ https://ncbi.nlm.nih.gov/pubmed/21654216 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/chan.5.4.16510 |
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