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Engineered interaction between SUR1 and Kir6.2 that enhances ATP sensitivity in K(ATP) channels
The ATP-sensitive potassium (K(ATP)) channel consisting of the inward rectifier Kir6.2 and SUR1 (sulfonylurea receptor 1) couples cell metabolism to membrane excitability and regulates insulin secretion. Inhibition by intracellular ATP is a hallmark feature of the channel. ATP sensitivity is conferr...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
The Rockefeller University Press
2012
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3409095/ https://ncbi.nlm.nih.gov/pubmed/22802363 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1085/jgp.201210803 |
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