Phosphorylation at Ser-129 but Not the Phosphomimics S129E/D Inhibits the Fibrillation of α-Synuclein

α-Synuclein (α-syn) phosphorylation at serine 129 is characteristic of Parkinson disease (PD) and related α-synulceinopathies. However, whether phosphorylation promotes or inhibits α-syn aggregation and neurotoxicity in vivo remains unknown. This understanding is critical for elucidating the role of...

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Autors principals: Paleologou, Katerina E., Schmid, Adrian W., Rospigliosi, Carla C., Kim, Hai-Young, Lamberto, Gonzalo R., Fredenburg, Ross A., Lansbury, Peter T., Fernandez, Claudio O., Eliezer, David, Zweckstetter, Markus, Lashuel, Hilal A.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2008
Matèries:
Protein Synthesis, Post-Translational Modification, and Degradation
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2423264/
https://ncbi.nlm.nih.gov/pubmed/18343814
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M800747200
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