Granzymes are the essential downstream effector molecules for the control of primary virus infections by cytolytic leukocytes

Analysis of perforin-deficient mice has identified the cytolytic pathway and perforin as the preeminent effector molecule in T cell-mediated control of virus infections. In this paper, we show that mice lacking both granzyme A (gzmA) and granzyme B (gzmB), which are, beside perforin, key constituent...

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Main Authors: Müllbacher, Arno, Waring, Paul, Tha Hla, Ron, Tran, Thao, Chin, Seow, Stehle, Thomas, Museteanu, Crisan, Simon, Markus M.
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 1999
Teme:
Biological Sciences
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC24171/
https://ncbi.nlm.nih.gov/pubmed/10570179
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