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Granzymes are the essential downstream effector molecules for the control of primary virus infections by cytolytic leukocytes

Analysis of perforin-deficient mice has identified the cytolytic pathway and perforin as the preeminent effector molecule in T cell-mediated control of virus infections. In this paper, we show that mice lacking both granzyme A (gzmA) and granzyme B (gzmB), which are, beside perforin, key constituent...

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Published in:Proc Natl Acad Sci U S A
Main Authors: Müllbacher, Arno, Waring, Paul, Tha Hla, Ron, Tran, Thao, Chin, Seow, Stehle, Thomas, Museteanu, Crisan, Simon, Markus M.
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 1999
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC24171/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10570179/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.96.24.13950
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