Proteasomal degradation restricts the nuclear lifespan of AID

Activation-induced cytidine deaminase (AID) initiates all postrearrangement processes that diversify the immunoglobulin repertoire by specific deamination of cytidines at the immunoglobulin (Ig) locus. As uncontrolled expression of AID is potentially mutagenic, different types of regulation, particu...

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Main Authors: Aoufouchi, Said, Faili, Ahmad, Zober, Carole, D'Orlando, Orietta, Weller, Sandra, Weill, Jean-Claude, Reynaud, Claude-Agnès
Format: Artigo
Jezik:Inglês
Izdano: The Rockefeller University Press 2008
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Articles
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2413033/
https://ncbi.nlm.nih.gov/pubmed/18474627
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20070950
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