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Proteasomal degradation restricts the nuclear lifespan of AID
Activation-induced cytidine deaminase (AID) initiates all postrearrangement processes that diversify the immunoglobulin repertoire by specific deamination of cytidines at the immunoglobulin (Ig) locus. As uncontrolled expression of AID is potentially mutagenic, different types of regulation, particu...
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| Главные авторы: | , , , , , , |
|---|---|
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
The Rockefeller University Press
2008
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2413033/ https://ncbi.nlm.nih.gov/pubmed/18474627 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20070950 |
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