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Protein Structure Fitting and Refinement Guided by cryoEM Density

For many macromolecular assemblies, both a cryoEM map and atomic structures of its component proteins are available. Here, we describe a method for fitting and refining a component structure within its map at resolutions better than ∼14 Å. The atomic positions are optimized with respect to a scoring...

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Detalhes bibliográficos
Main Authors: Topf, Maya, Lasker, Keren, Webb, Ben, Wolfson, Haim, Chiu, Wah, Sali, Andrej
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2409374/
https://ncbi.nlm.nih.gov/pubmed/18275820
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2007.11.016
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