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Model of human low-density lipoprotein and bound receptor based on CryoEM

Human plasma low-density lipoproteins (LDL), a risk factor for cardiovascular disease, transfer cholesterol from plasma to liver cells via the LDL receptor (LDLr). Here, we report the structures of LDL and its complex with the LDL receptor extracellular domain (LDL·LDLr) at extracellular pH determin...

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Detalhes bibliográficos
Main Authors: Ren, Gang, Rudenko, Gabby, Ludtke, Steven J., Deisenhofer, Johann, Chiu, Wah, Pownall, Henry J.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2010
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2798884/
https://ncbi.nlm.nih.gov/pubmed/20080547
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0908004107
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