Interprotofilament interactions between Alzheimer's Aβ(1–42) peptides in amyloid fibrils revealed by cryoEM

Alzheimer's disease is a neurodegenerative disorder characterized by the accumulation of amyloid plaques in the brain. This amyloid primarily contains amyloid-β (Aβ), a 39- to 43-aa peptide derived from the proteolytic cleavage of the endogenous amyloid precursor protein. The 42-residue-length...

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Bibliographic Details
Main Authors: Zhang, Rui, Hu, Xiaoyan, Khant, Htet, Ludtke, Steven J., Chiu, Wah, Schmid, Michael F., Frieden, Carl, Lee, Jin-Moo
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2009
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2660777/
https://ncbi.nlm.nih.gov/pubmed/19264960
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0901085106
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