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Hollow core of Alzheimer’s Aβ(42) amyloid observed by cryoEM is relevant at physiological pH
Recent cryoEM density maps of Aβ(42) fibrils obtained at low pH revealed two protofilaments winding around a hollow core raising the question if such tubular structures also exist at physiological pH. Based on the cryoEM measurements and on NMR data, we probe amyloid fibril organizations correspondi...
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| Main Authors: | , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
National Academy of Sciences
2010
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2922530/ https://ncbi.nlm.nih.gov/pubmed/20660780 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1004704107 |
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