Cardiomyocyte-restricted knockout of STAT3 results in higher sensitivity to inflammation, cardiac fibrosis, and heart failure with advanced age

Cytokines and inflammation have been implicated in the pathogenesis of heart failure. For example, IL-6 family cytokines and the gp130 receptor play important roles in cardiac myocyte survival and hypertrophy. Signal transducer and activator of transcription 3 (STAT3) is a major signaling protein th...

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Detalhes bibliográficos
Main Authors: Jacoby, Jörg J., Kalinowski, April, Liu, Mu-Gen, Zhang, Samuel S.-M., Gao, Qian, Chai, Gui-Xuan, Ji, Lan, Iwamoto, Yoshiki, Li, En, Schneider, Michael, Russell, Kerry S., Fu, Xin-Yuan
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2003
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC240721/
https://ncbi.nlm.nih.gov/pubmed/14566054
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2134694100
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