Cardiomyocyte-restricted knockout of STAT3 results in higher sensitivity to inflammation, cardiac fibrosis, and heart failure with advanced age

Cytokines and inflammation have been implicated in the pathogenesis of heart failure. For example, IL-6 family cytokines and the gp130 receptor play important roles in cardiac myocyte survival and hypertrophy. Signal transducer and activator of transcription 3 (STAT3) is a major signaling protein th...

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Autors principals: Jacoby, Jörg J., Kalinowski, April, Liu, Mu-Gen, Zhang, Samuel S.-M., Gao, Qian, Chai, Gui-Xuan, Ji, Lan, Iwamoto, Yoshiki, Li, En, Schneider, Michael, Russell, Kerry S., Fu, Xin-Yuan
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2003
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC240721/
https://ncbi.nlm.nih.gov/pubmed/14566054
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2134694100
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